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About VSL#3

The poly-biotic with more bacteria

What's in VSL#3

VSL#3 is the world’s most concentrated poly-biotic1 with 450 billion bacteria in every sachet, and even better, these bacteria come from not one but eight different bacterial strains, making it a combination poly-biotic.2

Why is more bacteria important?

When it comes to beneficial bacteria, more is better

It’s a long and difficult journey to your gut and some bacteria get lost on the way. The high concentration of bacteria (and specific bacterial strains) in VSL#3 ensures enough bacteria reach the colon.2,3

Approximately 100 trillion bacteria live in the human gut. As this is such a lot we need all the billions of bacteria in VSL#3 to make a difference.

Why is a combination poly-biotic important?

Different bacterial strains all have a slightly different effect on your body,
so having a combination is a good thing

It has been scientifically proven that combination probiotics (combination poly-biotics) improve symptoms such as bloating and pain significantly more than single probiotics.

There is good evidence to show no significant difference in pain score or bloating score for single probiotics, both as a group and individually, compared with placebo. There is a significant difference for combined probiotics, with the probiotic giving significantly less pain and bloating.

A recent report from NICE (the National Institute for Health and Care Excellence) and the Royal College of Nurses.4

The unique VSL#3 formulation contains eight strains of beneficial live bacteria (also known as ‘good’ bacteria), including several strains of the all-important lactobacilli and bifidobacteria. These strains have been carefully selected for the best results:2

These bacteria have been purposely selected,3 carefully cultivated and mixed proportionally to survive gastric acid, bile, and pancreatic secretions. To preserve the bacteria, as part of the preparation process they are freeze-dried. Freeze drying preserves the bacteria until VSL#3 reaches the stomach, where the bacteria “wake up” and are able to get to work.

How does VSL#3 compare with other bacterial supplements on the market?

With 450 billion bacteria per sachet,2 VSL#3 has substantially more bacteria per dose than any of the leading supplements on the market.1 This means the right amount of bacteria reaches your gut.

No. of strains of bacteria

No. of strains of bacteria

No. of bacteria (billions) per dose

No. of bacteria (billions) per dose

With eight different bacterial strains per sachet,2 VSL#3 has more bacterial strains per dose than many of the leading supplements on the market.1 This gives your gut the combination of bacteria it needs.

1. Data on File, Ferring UK Ltd.    2. Chapman T et al. Drugs 2006;66(10):1371-87.
3. Bezkorovainy A. Am J Clin Nutr 2001;73(suppl):399S-405S.
4. Clinical Practice Guideline. Irritable bowel syndrome in adults: Diagnosis and management of irritable bowel syndrome in primary care.

Healthcare professional information


1. Chapman T et al. Drugs 2006;66(10):1371-87.
2. Data on File, Ferring UK Ltd.
3. Kim HJ et al. Aliment Pharmacol Ther 2003;17:895-904.
4. Kim HJ et al. Neurogastroentero Motil 2005;17:687-696.
5. Wong. Dig Dis Sci. 2015 Jan; 60. 2014.

Due to the European Food Safety Authority (EFSA) rulings regarding the use of the terminology "probiotic", we now refer to VSL#3 as a poly-biotic which highlights its combination of 8 different strains and 450 billion bacteria.


July 2016